Role for Granulocyte Colony Stimulating Factor in Angiotensin II–Induced Neutrophil Recruitment and Cardiac Fibrosis in Mice Hui-Min Jiang,1 Hong-Xia Wang,1 Hui Yang1, Xiang-Jun Zeng,1 Chao-Shu Tang,1 Jie Du,2 and Hui-Hua Li1
نویسنده
چکیده
background Granulocyte colony stimulating factor (G-CSF) is a key mediator of neutrophil infiltration and is profibrotic in the liver, lung, and infarcted heart, but its roles in angiotensin II (Ang II)–induced hypertension and cardiac remodeling have not been fully determined. Thus, we sought to investigate the causal relation of G-CSF to neutrophil recruitment and cardiac fibrosis in C57BL/6J mice.
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تاریخ انتشار 2013